期刊
INTERNATIONAL JOURNAL OF CANCER
卷 122, 期 1, 页码 1-4出版社
WILEY
DOI: 10.1002/ijc.23233
关键词
cell lines; misidentification; cross-contamination; authentication; short tandem repeat; HeLa; MDA-MB-435; misuse
类别
From HeLa and its multiple identities, to MDA-MB-435, erroneously and widely used as breast cancer cells, the history of cancer cell lines is rich in misidentification and cross-contamination events. Despite the fact that these problems were regularly signaled during the last decades, many actors of research still seem to ignore them. A never-ending story? Solutions exist, notably based on recent technical advances in cell line authentication (short tandem repeat analysis). However, a collaborative action involving users of cell lines, cell banks, journals and funding agencies is needed to achieve success. (C) 2007 Wiley-Liss, Inc.
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