期刊
FEBS LETTERS
卷 582, 期 2, 页码 365-371出版社
WILEY
DOI: 10.1016/j.febslet.2007.12.006
关键词
MAP kinase; osteoblast; differentiation; bone; tyrosine phosphorylation
资金
- NIDCR NIH HHS [R01 DE016107, R01 DE016107-03, R01 DE016107-04, R01 DE016107-01, R01 DE016107-02] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE016107] Funding Source: NIH RePORTER
NELL1 is an extracellular protein inducing osteogenic differentiation and bone formation of osteoblastic cells. To elucidate the intracellular signaling cascade evoked by NELL1, we have shown that NELL1 protein transiently activates the MAPK signaling cascade, induces the phosphorylation of Runx2, and promotes the rapid intracellular accumulation of Tyr-phosphorylated proteins. Unlike BMP2, NELL1 protein does not activate the Smad signaling cascade. These findings suggest that upon binding to a specific receptor NELL1 transduces an osteogenic signal through activation of certain Tyr-kinases associated with the Ras-MAPK cascade, and finally leads to the osteogenic differentiation. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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