SERS: a versatile tool in chemical and biochemical diagnostics

Raman spectroscopy is a valuable tool in various research fields. The technique yields structural information from all kind of samples often without the need for extensive sample preparation. Since the Raman signals are inherently weak and therefore do not allow one to investigate substances in low concentrations, one possible approach is surface-enhanced (resonance) Raman spectroscopy. Here, rough coin metal surfaces enhance the Raman signal by a factor of 10(4)-10(15), depending on the applied method. In this review we discuss recent developments in SERS spectroscopy and their impact on different research fields.