期刊
FEBS LETTERS
卷 582, 期 2, 页码 243-248出版社
WILEY
DOI: 10.1016/j.febslet.2007.12.011
关键词
roscovitine; vascular smooth muscle cell; angiotensin II; extracellular signal-regulated kinase1/2; c-Jun
Roscovitine is a potent CDK inhibitor often used as a biological tool in cell-cycle studies, but its working mechanism and real targets in vascular smooth muscle cells (VSMCs) remain unclear. In this study, we observed that ERK1/2 phosphorylation induced by Ang II was abrogated by pretreating VSMCs with roscovitine for 15 h. Pretreating VSMCs with roscovitine also inhibited Ang II-induced c-Jun expression and phosphorylation. We further demonstrated that roscovitine could suppress the DNA binding activity of c-Jun and activation of angiotensinogen promoter by Ang II. These results suggest that roscovitine represses Ang II-induced angiotensinogen expression by inhibiting activation of ERK1/2 and c-Jun. (C) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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