期刊
BRITISH JOURNAL OF NUTRITION
卷 99, 期 6, 页码 1335-1343出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114507862350
关键词
acid-base balance; urine pH; potential renal acid load; European prospective investigation into cancer and nutrition; EPIC-Norfolk
资金
- British Heart Foundation Funding Source: Medline
- Cancer Research UK Funding Source: Medline
- Medical Research Council [MC_U105630924] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Department of Health Funding Source: Medline
- MRC [MC_U105630924] Funding Source: UKRI
Evidence exists that a more acidic diet is detrimental to bone health. Although more precise methods exist for measurement of acid-base balance, urine pH reflects acid-base balance and is readily measurable but has not been related to habitual dietary intake in general populations. The present study investigated the relationship between urine pH and dietary acid-base load (potential renal acid load; PRAL) and its contributory food groups (fruit and vegetables, meats, cereal and dairy foods). There were 22038 men and women aged 39-78 years living in Norfolk (UK) with casual urine samples and dietary intakes from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk FFQ. A sub-study (n 363) compared pH in casual samples and 24 h urine and intakes from a 7d diary and the FFQ. A more alkaline diet (low PRAL), high fruit and vegetable intake and lower consumption of meat was significantly associated with a more alkaline urine pH before and after adjustment for age, BMI, physical activity and smoking habit and also after excluding for urinary protein, glucose, ketones, diagnosed high blood pressure and diuretic medication. In the sub-study the strongest relationship was found between the 24 h urine and the 7d diary. In conclusion, a more alkaline diet, higher fruit and vegetable and lower meat intake were related to more alkaline urine with a magnitude similar to intervention studies. As urine pH relates to dietary acid-base load its use to monitor change in consumption of fruit and vegetables, in individuals, warrants further investigation.
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