期刊
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
卷 183, 期 1, 页码 82-89出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426500701557021
关键词
microwave-assisted; Biginelli reaction; thioxopyrimidine; synthesis; cyclocondensation; multicomponent reaction
The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (la) and 5-benzoyl-4-(2-chlorophenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (1b) were synthesized using the Biginelli three-component cyclocondensation reaction of a beta-diketone, arylaldehyde, and thiourea under microwave irradiation. Thiazolopyrimidine (2), (3) and pyrimido[2,3-b]thiazine (4) derivatives were obtained by a Simple one-pot condensation reaction of starting compound 1b and 2-bromopropionic acid, bromoacetic acid and 3-bromopropionic acid, respectively. These reactions performed under microwave irradiation and conventional conditions. That study is suggested a simple anal efficient route for the preparation of 1,2,3,4-tetrahydro-2-thioxopyrimidine and derivatives.
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