期刊
MAGNETIC RESONANCE IN MEDICINE
卷 59, 期 1, 页码 52-58出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21447
关键词
proton magnetic resonance spectroscopic imaging; short echo time; metabolite concentrations; rat brain; cerebral ischemia
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042005] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01NS042005, R01 NS042005, R01 NS042005-06] Funding Source: Medline
Proton spectroscopy allows the simultaneous quantification of a high number of metabolite concentrations termed the neurochemical profile. The spin echo full intensity acquired localization (SPECIAL) scheme with an echo time of 2.7 ms was used at 9.4T for excitation of a slab parallel to a home-built quadrature surface coil in conjunction with phase encoding in the two remaining spatial dimensions to yield an effective spatial resolution of 1.7 mu L. The absolute concentrations of at least 10 metabolites were calculated from the spectra of individual voxels using LCModel analysis. The calculated concentrations were used for constructing quantitative metabolic maps of the neurochemical profile in normal and pathological rat brain. Summation of individual spectra was used to assess the neurochemical profile of unique brain regions, such as corpus callosum, in rat for the first time. Following focal ischemia in rat pups, imaging the neurochemical profile indicated increased choline groups in the ischemic core and increased glutamine in the penumbra, which is proposed to reflect glutamate excito-toxicity. We conclude that it is feasible to achieve a sensitivity that is sufficient for quantitative mapping of the neurochemical profile at microliter spatial resolution. Magn Reson Med 59: 52-58, 2008. (C) 2007 Wiley-Liss, Inc.
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