A comparative study of microwave assisted and conventional synthesis of 2,3-dihydro-2-aryl-4-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-ylamino]-1,5-benzothiazepines and its antimicrobial activity

A variety of 2,3-dihydro-2-aryl-4-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-ylamino]- 1,5-benzothiazipine 6a-j were synthesized from N-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2- yl]-cinnamamide derivatives 4a-j. The structures of these compounds were confirmed by IR, NMR (H-1 & C-13) & mass spectral analysis. A considerable increase in the reaction rate has been observed with better yield using microwave irradiation in comparison to conventional thermal treatment. The newly synthesized compounds were evaluated for antimicrobial activity against variety of bacterial strains and some of these compounds have shown significant antibacterial and antifungal activities.