期刊
NEUROPSYCHOPHARMACOLOGY
卷 33, 期 1, 页码 18-41出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.npp.1301559
关键词
long-term potentiation; long-term depression; NMDA receptors; AMPA receptors; hippocampus; addiction
Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a psychoactive substance, impact the brain by modifying the activity and organization of specific neural circuitry. A major mechanism by which the neural activity generated by an experience modifies brain function is via modifications of synaptic transmission; that is, synaptic plasticity. Here, we review current understanding of the mechanisms of the major forms of synaptic plasticity at excitatory synapses in the mammalian brain. We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据