期刊
CELL RESEARCH
卷 18, 期 1, 页码 85-98出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cr.2007.115
关键词
MutS; MutL; microsatellite instability; cancer
类别
资金
- NATIONAL CANCER INSTITUTE [R01CA115942] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072756] Funding Source: NIH RePORTER
- NCI NIH HHS [CA115942] Funding Source: Medline
- NIGMS NIH HHS [GM072756] Funding Source: Medline
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous recombination and was recently shown to play a role in DNA damage signaling in eukaryotic cells. Escherichia coli MutS and MutL and their eukaryotic homologs, MutS alpha and MutL alpha, respectively, are key players in MMR-associated genome maintenance. Many other protein components that participate in various DNA metabolic pathways, such as PCNA and RPA, are also essential for MMR. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including hereditary non-polyposis colorectal cancer, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
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