期刊
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
卷 34, 期 5, 页码 1339-1344出版社
KOREAN CHEMICAL SOC
DOI: 10.5012/bkcs.2013.34.5.1339
关键词
Glycosyl ergosterol; Glycosyl 5,6-dihydroergosterol; Glycosylation; Inhibitory activity; NO production
资金
- Next Generation BioGreen 21 program, Rural Development Administration, Republic of Korea [PJ007985]
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012R1A1A2007074]
- National Research Foundation of Korea [2012R1A1A2007074] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of 100 mu M.
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