期刊
CELL RESEARCH
卷 18, 期 1, 页码 184-197出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2007.116
关键词
base unstacking; MMR; BER; NER; ATPase; nuclease; glycosylase
类别
资金
- Intramural NIH HHS Funding Source: Medline
A fundamental question in DNA repair is how a lesion is detected when embedded in millions to billions of normal base pairs. Extensive structural and functional studies reveal atomic details of DNA repair protein and nucleic acid interactions. This review summarizes seemingly diverse structural motifs used in lesion recognition and suggests a general mechanism to recognize DNA lesion by the poor base stacking. After initial recognition of this shared structural feature of lesions, different DNA repair pathways use unique verification mechanisms to ensure correct lesion identification and removal.
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