期刊
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
卷 32, 期 2, 页码 656-658出版社
KOREAN CHEMICAL SOC
DOI: 10.5012/bkcs.2011.32.2.656
关键词
Biginelli reaction; Heterogeneous catalysis; PPA-SiO2; Multi-component reactions
资金
- Islamic Azad University, Mashhad Branch
A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-SiO2) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.
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