期刊
NATURE REVIEWS IMMUNOLOGY
卷 9, 期 1, 页码 62-70出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2470
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资金
- Arthritis Research Campaign UK
- Wellcome Trust
- British Heart Foundation
- Medical Research Council UK
- MRC [G0400327] Funding Source: UKRI
- Medical Research Council [G0400327] Funding Source: researchfish
Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. in this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. in addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.
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