期刊
NATURE REVIEWS CANCER
卷 9, 期 1, 页码 40-55出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2543
关键词
-
类别
资金
- German Research Foundation [ZO 40/12-1]
- Tumourzentrum Heidelberg/Mannheim
Tumours progress through a cascade of events that enable the formation of metastases. Some of the components that are required for this fatal process are well established. Tetraspanins, however, have only recently received attention as both metastasis suppressors and metastasis promoters. This late appreciation is probably due to their capacity to associate with various molecules, which they recruit into special membrane microdomains, and their abundant presence in tumour-derived small vesicles that aid intercellular communication. It is reasonable to assume that differences in the membrane and vesicular web components that associate with individual tetraspanins account for their differing abilities to promote and suppress metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据