期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 76, 期 8, 页码 1941-1952出版社
SPRINGER
DOI: 10.1007/s11538-014-9992-0
关键词
Chromosome associations in meiotic cells; Probability distributions on regular graphs
资金
- FONDECYT (Chile) [1120160]
- Ministerio de Ciencia e Innovacion (Spain) [BFU 2009/10987]
The establishment of associations between bivalents from Mus domesticus spermatocytes is a common phenomenon that shows up during the first prophase of meiotic nuclei. In each nucleus, a seemingly random display of variable size clusters of bivalents in association is observed. These associations originate a particular nuclear architecture and determine the probability of encounters between chromosome domains. Hence, the type of randomness in associations between bivalents has nontrivial consequences. We explore different models for randomness and the associated bivalent probability distributions and find that a simple model based on randomly coloring a subset of vertices of a 6-regular graph provides best agreement with microspreads observations. The notion of randomness is thereby explained in conjunction with the underlying local geometry of the nuclear envelope.
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