期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 75, 期 1, 页码 82-93出版社
SPRINGER
DOI: 10.1007/s11538-012-9795-0
关键词
Hepatitis A; Hepatitis C; Competitive exclusion principle; Mathematical models
资金
- HCFMUSP [LIM-01]
- CNPq
- FAPESP
We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.
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