期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 74, 期 5, 页码 1143-1170出版社
SPRINGER
DOI: 10.1007/s11538-011-9712-y
关键词
Biomechanics; Myofibroblasts; Transforming growth factor-beta; Contraction
资金
- Australian Research Council [DP0878011]
- Institute of Health and Biomedical Innovation at Queensland University of Technology
- Centre for Mathematical Biology, Mathematical Institute at the University of Oxford
- Queensland University of Technology
- Royal Society
- King Abdullah University of Science and Technology (KAUST) [KUK-C1-013-04]
- Australian Research Council [DP0878011] Funding Source: Australian Research Council
Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor beta (TGF beta) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGF beta and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched.
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