期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 72, 期 5, 页码 1143-1165出版社
SPRINGER
DOI: 10.1007/s11538-009-9485-8
关键词
Pseudomonas aeruginosa biofilms; Quorum sensing
资金
- NIH [R01-GM067248]
- DoD
- Chicago Chapter of the ARCS Foundation
In this paper, we study quorum sensing in Pseudomonas aeruginosa biofilms. Quorum sensing is a process where bacteria monitor their population density through the release of extra-cellular signalling molecules. The presence of these molecules affects gene modulation leading to changes in behaviour such as the release of virulence factors. Here, we use numerical methods to approximate a 2-D model of quorum sensing. It is observed that the shape of the biofilm can have a profound effect on the onset of quorum sensing. This has serious repercussions for experimental observations since biofilms of the same biomass but different shapes can produce quite different results.
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