期刊
JOURNAL OF ANXIETY DISORDERS
卷 23, 期 1, 页码 54-59出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.janxdis.2008.03.015
关键词
Post-traumatic stress disorder (PTSD); Transcranial magnetic stimulation (TMS); Psychological desensitization; Psychological therapies; Extinction
资金
- Intramural NIH HHS [Z01 MH002755-07, Z01 MH002757-04] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [Z01MH002757, Z01MH002755] Funding Source: NIH RePORTER
Treatment for anxiety and post-traumatic stress disorder (PTSD) includes exposure therapy and medications, but some patients are refractory. Few studies of repetitive transcranial magnetic stimulation (rTMS) for anxiety or PTSD exist. In this preliminary report, rTMS was combined with exposure therapy for PTSD. Nine subjects with chronic, treatment-refractory PTSD were studied in a placebo-controlled, crossover design of imaginal exposure therapy with rTMS (1 Hz) versus sham. PTSD symptoms, serum and 24 h urine were obtained and analyzed. Effect sizes for PTSD symptoms were determined using Cohen's d. Active rTMS showed a larger effect size of improvement for hyperarousal symptoms compared to sham; 24-h urinary norepinephrine and serum T4 increased: serum prolactin decreased. Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD. (C) 2008 Elsevier Ltd. All rights reserved.
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