4.2 Article

Antidiabetic Activity of Afobazole in Wistar Rats

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SPRINGER
DOI: 10.1007/s10517-018-4233-4

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type 2 diabetes mellitus; Afobazole; metformin; streptozotocin

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Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.

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