期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 153, 期 4, 页码 513-515出版社
SPRINGER
DOI: 10.1007/s10517-012-1754-0
关键词
assisted reproductive technologies; protamines (PRM1, PRM2); fertilin-beta (ADAM-2); reverse transcription quantitative PCR
资金
- Ministry of Education and Science (State Contract of the Russian Federation) [16.22.12.2009]
We studied the relationship between the levels of protamines 1 and 2 (PRM1 and PRM2) and fertilin-beta (ADAM-2) mRNA expression and outcomes of infertility treatment using assisted reproductive technologies was studied. Analysis of the relationships between the outcomes of in vitro fertilization and embryo transfer and profiles of the expression of seminal genes PRM1, PRM2, ADAM-2 mRNA, evaluated by reverse transcription quantitative PCR was carried out in 79 couples. Significant differences in the expression of seminal PRM1, PRM2, ADAM-2 mRNA were detected in couples with different outcomes of in vitro fertilization and embryo transfer. The levels of seminal gene expression are potential predictors of the efficiency of in vitro fertilization and embryo transfer.
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