On the Activation of Calcium-Dependent Proteolysis in Brain Neurons of Spontaneously Hypertensive Rats (SHR Strain)

Females of spontaneously hypertensive (SHR strain) and normotensive rats (WKY strain and Wistar) received drinking water with normal (80 mg/liter) or reduced concentration of Ca(2+) (8 mg/liter). Activity of calcium-dependent calpain protease in neurons did not differ in 18-day-old rat pups born and suckled by these animals. Our results are consistent with published data on normal metabolism of SHR rats up to the age of 30 days.