Role of Nitric Oxide in Activity Control of Mechanically Gated Ionic Channels in Cardiomyocytes: NO-Donor Study

Whole-cell ionic currents through mechanically gated chnnels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.