期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 150, 期 1, 页码 1-5出版社
SPRINGER
DOI: 10.1007/s10517-010-1052-7
关键词
isolated cardiomyocytes; whole-cell ionic currents; mechanically gated channels; NO-donors
资金
- Russian Foundation for Basic Research [09-04-01277-a]
Whole-cell ionic currents through mechanically gated chnnels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.
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