期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 149, 期 1, 页码 1-3出版社
SPRINGER
DOI: 10.1007/s10517-010-0859-6
关键词
sex; age; blood pressure; renal hypertension; nitric oxide
资金
- Federal Target Program Scientific and scientific-pedagogical personnel of innovative Russia in 2009-2013 [NK-30P]
The mean blood pressure did not depend on the sex of animals and was characterized by the same ontogenetic changes in males and females. The mean blood pressure in infantile and, particularly, in old rats was higher than in adult animals. The increase in blood pressure in old rats was accompanied by a decrease in NO production. Infantile rats were least resistant to the development of renal hypertension. The degree of hypertension in infantile and adult females was lower than in males. However, the concentration of NO in these females was higher than in male rats. Aging was accompanied by inversion of sex differences in the resistance to renal hypertension. The severity of hypertension in old females was greater than in males. It was accompanied by a significant age-related decrease in NO concentration in female animals. Our results indicate that NO plays an important role in sex differences in the resistance of infantile, adult, and old rats to hypertension, while the decrease in NO concentration during aging leads to blood pressure elevation in females and males.
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