期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 147, 期 3, 页码 345-348出版社
SPRINGER
DOI: 10.1007/s10517-009-0505-3
关键词
peroxisome proliferation activating receptors; liver X receptors; retinoid X receptors; macrophages; time course of inflammation
资金
- Russian Foundation for Basic Research [06-0448273, 07-04-00864]
The content of peroxisome proliferation activating proteins PPAR-alpha and PPAR-gamma, liver X receptors (LXR), and retinoid X receptors (RXR) and activity of PPAR-alpha, PPAR-gamma, and PPAR-delta binding to DNA response elements in C57Bl/6 mouse macrophages were studied during different phases of aseptic inflammation, induced by intraperitoneal injection of 50 mg/kg zymosan A. The DNA-binding activities of PPAR-alpha and PPAR-gamma and the levels of PPAR-alpha, PPAR-gamma, LXR, and RXR in peritoneal macrophages dropped on days 1 and 3 after zymosan injection. On days 7 and 14 the DNA-binding activity of PPAR-gamma and content of PPAR-gamma and LXR-beta protein increased in comparison with the control, while the DNA-binding activity and content of PPAR-alpha in the cells remained low. Recovery of RXR protein content in macrophages was observed only on day 14 after zymosan injection.
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