期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 147, 期 1, 页码 132-146出版社
SPRINGER
DOI: 10.1007/s10517-009-0432-3
关键词
brain trauma; mesenchymal stem cells; neural stem cells; xenotransplantation; neurogenesis
资金
- Diod Company
We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.
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