期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 148, 期 6, 页码 937-939出版社
SPRINGER
DOI: 10.1007/s10517-010-0856-9
关键词
diabetes mellitus; endocrine beta-cells; apoptosis; streptozotocin
Administration of streptozotocin caused selective damage to endocrine beta-cells in rat pancreatic islets, which was related to activation of apoptosis. The cytotoxic effect of streptozotocin was associated not only with DMA damage due to dysfunction of the antioxidant defense system, but also with activation of the caspase cascade and TNF-related apoptosis-inducing ligand.
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