期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 146, 期 1, 页码 33-35出版社
SPRINGER
DOI: 10.1007/s10517-008-0233-0
关键词
prenatal hyperhomocysteinemia; N-methyl-D-aspartate (NMDA); homocystein; homocysteinic acid
We found that methionine added to the ration of pregnant rats (1 g/kg body weight) induced sustained hyperhomocysteinemia and led to the formation of sustained oxidative stress in the brain of their progeny. Newborn animals were characterized by lower body weight, SOD deficiency in the brain, increased neuronal death, and desensitization of NMDA receptors. These factors are associated with impaired cognitive capacity in the Morris test.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据