期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 145, 期 2, 页码 218-222出版社
SPRINGER
DOI: 10.1007/s10517-008-0054-1
关键词
Alzheimer disease; microtubules; tacrine; amiridine; memantine
In in vitro experiments, amiridine in concentration of 100, 200, and 300 mu M restored disturbed structure of microtubules assembled from tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease. Tacrine in a concentration of 100, 250, and 500 mu M inhibited phosphorylation of tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease, while memantine and amiridine in the specified concentrations had no effect on phosphorylation.
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