期刊
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
卷 18, 期 1, 页码 117-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.chc.2008.07.002
关键词
Hyperactivity; Semi-starvation; Osteoporosis; Amenorrhea; Hypoleptinemia; Hypedeptinema; Weight loss
类别
Hypoleptinemia is a key endocrinological feature of anorexia nervosa (AN). Several symptoms in acute AN are related to the low circulating leptin levels including amenorrhea and semi-starvation-induced hyperactivity. The drop in leptin levels results from the loss of fat mass; once leptin levels fall below specific thresholds the hypothalamic-pituitary-gonadal and -thyroid axes are down-regulated; in contrast, the hypothalamic-pituitary-adrenal axis is up-regulated. Hypoleptinemia is the major signal underlying both somatic and behavioral adaptations to starvation. Because the mechanisms involved in this adaptation are similar in rodents and humans, rodent models can be used to investigate the relevant central pathways which underly the respective starvation-induced symptoms. During therapeutically induced weight gain, leptin levels can intermittently increase above normal concentrations. This hyperleptinemia could predispose to renewed weight loss.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据