期刊
BRITISH MEDICAL BULLETIN
卷 103, 期 1, 页码 89-114出版社
OXFORD UNIV PRESS
DOI: 10.1093/bmb/lds021
关键词
adult hippocampal neurogenesis; neural stem cells; diet; nutrition; learning and memory; mood
资金
- Research Councils UK
- Psychiatry Research Trust
- Welton Foundation
- Malaysian trust Council MARA
Over the last 8 years, emerging studies bridging the gap between nutrition and mental health have resolutely established that learning and memory abilities as well as mood can be influenced by diet. However, the mechanisms by which diet modulates mental health are still not well understood. In this article, a review of the literature was conducted using PubMed to identify studies that provide functional implications of adult hippocampal neurogenesis (AHN) and its modulation by diet. One of the brain structures associated with learning and memory as well as mood is the hippocampus. Importantly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists. The exact roles of these newborn neurons in learning, memory formation and mood regulation remain elusive. Nevertheless, there has been accumulating evidence linking cognition and mood to neurogenesis occurring in the adult hippocampus. Therefore, modulation of AHN by diet emerges as a possible mechanism by which nutrition impacts on mental health. This area of investigation is new and needs attention because a better understanding of the neurological mechanisms by which nutrition affect mental health may lead to novel dietary approaches for disease prevention, healthier ageing and discovery of new therapeutic targets for mental illnesses.
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