期刊
BRITISH JOURNAL OF SURGERY
卷 105, 期 12, 页码 1639-1649出版社
WILEY
DOI: 10.1002/bjs.10900
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资金
- Swedish Research Council
- Swedish Cancer Society
- Amgen
- Astra-Zeneca
- Bayer
- Celgene
- MedImmune
- Merck Serrono
- Merrimack
- Sanofi
Background: The aim was to define the pathological response in lymph nodes following neoadjuvant chemotherapy for oesophageal adenocarcinoma and to quantify any associated survival benefit. Methods: Lymph nodes retrieved at oesophagectomy were examined retrospectively by two pathologists for evidence of a response to chemotherapy. Patients were classified as lymph node-negative (either negative nodes with no evidence of previous tumour involvement or negative with evidence of complete regression) or positive (allocated a lymph node regression score based on the proportion of fibrosis to residual tumour). Lymph node responders (score 1, complete response; 2, less than 10 per cent remaining tumour; 3, 10-50 per cent remaining tumour) and non-responders (score 4, more than 50 per cent viable tumour; 5, no response) were compared in survival analyses using Kaplan-Meier and Cox regression analysis. Results: Among 377 patients, 256 had neoadjuvant chemotherapy. Overall, 68 of 256 patients (26.6 per cent) had a lymph node response and 115 (44.9 per cent) did not. The remaining 73 patients (28.5 per cent) had negative lymph nodes with no evidence of regression. Some patients had a lymph node response in the absence of a response in the primary tumour (27 of 99, 27 per cent). Lymph node responders had a significant survival benefit (P < 0.001), even when stratified by patients with or without a response in the primary tumour. On multivariable analysis, lymph node responders had decreased overall (hazard ratio 0.53, 95 per cent c.i. 0.36 to 0.78) and disease-specific (HR 0.42, 0.27 to 0.66) mortality, and experienced reduced local and systemic recurrence. Conclusion: Lymph node regression is a strong prognostic factor and may be more important than response in the primary tumour.
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