A comparative study of microwave-assisted and conventional synthesis of novel 2-(4-diethylamino-2-hydroxyphenyl)-3-substituted-thiazolidin-4-one derivatives

We report efficient and extremely fast procedures for the synthesis of 2-(4-diethylamino-2-hydroxy-phenyl)-3-substituted-thiazolidin-4-one using 4-diethylamino-2-hydroxybenzaldehyde, various amines and mercaptoacetic acid under microwave irradiation (mu w), and similarly conventional methods are used for comparison. A considerable increase in the reaction rate has been observed with a better yield in microwave technique. The structures of the compounds were confirmed by elemental and spectral analyses (H-1-NMR, C-13-NMR & Mass).