期刊
BRITISH JOURNAL OF SPORTS MEDICINE
卷 45, 期 2, 页码 95-100出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bjsm.2009.060285
关键词
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资金
- Ministerio de Educacion y Ciencia [DEP2006-56076-C06-04/ACTI]
- FEDER
- Consejeria de Educacion
- Cultura y Deportes del Gobierno de Canarias [2006/179 0001]
- Proyecto Interreg IIIB BIOPOLIS
- Fundacion del Instituto Canario de Investigacion del Cancer (FICIC)
- Cabildo de Gran Canaria
- Cabildo de Tenerife and La Caja de Canarias
- Proyecto Estructurante
- ULPGC
- Gobierno de Canarias
The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGN(n), polyglycine) or its transcriptional activity (CAG(n), polyglutamine). Shorter CAG and/or GGN repeats provide stronger androgen signalling and vice versa. To test the hypothesis that CAG and GGN repeat AR polymorphisms affect muscle mass and various variables of muscular strength phenotype traits, the length of CAG and GGN repeats was determined by PCR and fragment analysis and confirmed by DNA sequencing of selected samples in 282 men (28.6+/-7.6 years). Individuals were grouped as CAG short (CAG(S)) if harbouring repeat lengths of <= 21 and CAG long (CAG(I)) if CAG >21. GGN was considered short (GGN(S)) or long (GGN(L)) if GGN <= 23 or >23, respectively. No significant differences in lean body mass or fitness were observed between the CAG(S) and CAG(L) groups, or between GGN(S) and GGN(L) groups, but a trend for a correlation was found for the GGN repeat and lean mass of the extremities (r=-0.11, p=0.06). In summary, the lengths of CAG and GGN repeat of the AR gene do not appear to influence lean mass or fitness in young men.
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