期刊
BRITISH JOURNAL OF RADIOLOGY
卷 87, 期 1038, 页码 -出版社
BRITISH INST RADIOLOGY
DOI: 10.1259/bjr.20130490
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资金
- Indian Council for Medical Research (ICMR), New Delhi
- Father Muller Charitable Institution
- Father Muller Medical College
Objective: The study objective was to assess the effectiveness of a turmeric-and sandal wood oil-containing cream [Vicco (R) turmeric cream (VTC); Vicco Laboratories, Parel, India] on radiodermatitis in patients with head and neck cancer undergoing radiotherapy. Methods: A total of 50 patients with head and neck cancer requiring >60Gy of curative radiotherapy/chemoradiotherapy were enrolled in the study. The volunteers were randomly divided into two groups of 25 patients. Group 1 was assigned to a topical application of Johnson's (R) baby oil (Johnson & Johnson Ltd, Baddi, India) and Group 2 for VTC. Prophylactic application of the cream was initiated on Day 1 and continued every day until 2 weeks after the end of treatment. Both agents were symmetrically applied within the irradiated field five times a day, and the acute skin reactions were assessed twice weekly in accordance with the Radiation Therapy Oncology Group scores by an investigator who was unaware of the details. Results: The incidence of radiodermatitis increased with the exposure to radiation and was the highest in both groups at Week 7. However, a significant reduction in grades of dermatitis were seen in cohorts applying VTC at all time points, including 2 weeks post radiotherapy (p < 0.015 to p < 0.001). The occurrence of Grade 3 dermatitis was lower in the cohorts using VTC and was statistically significant (p < 0.01). Additionally, follow-up observations 2 weeks after the completion of radiotherapy also showed a reduced degree of radiodermatitis in cohorts applying VTC, which was significant (p = 0.015). Conclusion: VTC is shown to be effective in preventing radiodermatitis and needs to be validated in larger double-blind trials. Advances in knowledge: For the first time, this study shows that the turmeric-and sandal oil-based cream was effective in preventing radiation-induced dermatitis. Advances in knowledge: For the first time, this study shows that the turmeric- and sandal oil-based cream was effective in preventing radiation-induced dermatitis.
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