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Polyamine depletion partially reduces the radiation-induced cell death via cell cycle delay mediated by thioredoxin
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The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma
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Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1 alpha in non-small cell lung cancer
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High thioredoxin expression is associated with resistance to docetaxel in primary breast cancer
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A redox signature score identifies diffuse large B-cell lymphorna patients with a poor prognosis
ME Tome et al.
BLOOD (2005)
Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients
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Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors
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Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c
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BIOCHEMICAL PHARMACOLOGY (2004)
Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis
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Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity
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Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide
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Cysteine oxidation of tau and microtubule-associated protein-2 by peroxynitrite - Modulation of microtubule assembly kinetics by the thioredoxin reductase system
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Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth
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Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells
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The thioredoxin system - From science to clinic
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Thioredoxin inhibits microvascular endothelial capillary tubule formation
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Thioredoxin restores nitric oxide-induced inhibition of protein kinase C activity in lung endothelial cells
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A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines
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Thioredoxin reductase 1 expression in colon cancer:: Discrepancy between in vitro and in vivo findings
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Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif
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Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival
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The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins
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Characterization of human thioredoxin-like 2 -: A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme
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Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma
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Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses
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Expression of antioxidant enzymes in bronchial metaplastic and dysplastic epithelium
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Enhancement of metabolic oxidative stress-induced cytotoxicity by the thioredoxin inhibitor 1-methylpropyl 2-imidazolyl disulfide is mediated through the ASK1-SEK1-JNK1 pathway
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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
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Effects of a new anti-rheumatic drug KE-298 and its active metabolite: KE-758 on secretion of thioredoxin and on the level of intracellular glutathione in human monocytes and T cells
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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
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New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead
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Human thioredoxin reductase is efficiently inhibited by (2,2′:6′,2-terpyridine)platinum(II) complexes.: Possible implications for a novel antitumor strategy
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