期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 200, 期 4, 页码 290-299出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.111.101253
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资金
- Analysis Group
- Bristol-Myers Squibb
- Eli Lilly Company
- EPI-Q
- GlaxoSmithKline
- Johnson & Johnson Pharmaceuticals
- Ortho-McNeil Janssen Scientific Affairs
- Pfizer
- Sanofi-Aventis Groupe
- Shire US
- United States National Institute of Mental Health [R01MH070884, R01MH093612]
- NIMH [HHSN271200700030C]
- John D. and Catherine T. MacArthur Foundation
- Pfizer Foundation
- US Public Health Service [R13-MH066849, R01-MH069864, R01 DA016558]
- Fogarty International Center [FIRCA R03-TW006481]
- Pan American Health Organization (PAHO)
- Eli Lilly & Company Foundation
- Ortho-McNeil Pharmaceutical
- Shire
- State of Sao Paulo Research Foundation (FAPESP) [03/00204-3]
- Ministry of Health
- National Center for Public Health Protection
- Shenzhen Bureau of Health
- Shenzhen Bureau of Science, Technology, and Information
- Ministry of Social Protection
- European Commission [QLG5-1999-01042, SANCO 20041231]
- Piedmont Region (Italy)
- Fondo de Investigacion Sanitaria, Institut de Salud Carlos III, Spain [FIS 00/0028]
- Ministerio de Ciencia y Tecnologia, Spain [SAF 2000-158-CE]
- Departament de Salut, Generalitat de Catalunya, Spain, Institut de Salud Carlos III [CIBER CB06/02/0046, RETICS RD06/0011 REM-TAP]
- Government of India
- WHO
- United Nations Development Group (UNDG)
- Japan Ministry of Health, Labour and Welfare [H13-SHOGAI-023, H14-TOKUBETSU-026, H16-KOKORO-013]
- Lebanese Ministry of Public Health
- WHO (Lebanon)
- National Institute of Health/Fogarty International Center [R03 TW006481-01]
- Janssen Cilag
- Eli Lilly
- AstraZeneca
- Hikma Pharm
- Novartis
- National Institute of Psychiatry Ramon de la Fuente [INPRFMDIES 4280]
- National Council on Science and Technology [CONACyT-G30544-H]
- WHO (Geneva)
- WHO (Nigeria)
- Federal Ministry of Health, Abuja, Nigeria
- Health & Social Care Research & Development Division of the Public Health Agency
- Champalimaud Foundation
- Gulbenkian Foundation
- Foundation for Science and Technology (FCT)
- US National Institute of Mental Health [R01-MH059575, RO1-MH61905]
- National Institute of Drug Abuse
- South African Department of Health
- university of Michigan
- National Institute of Mental Health [U01-MH60220]
- Robert Wood Johnson Foundation [044708]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/00204-3] Funding Source: FAPESP
Background Associations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity. Aims To examine the associations of parent with respondent disorders. Method Data come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews. Results Although virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle-than low-/lower-middle-income countries, and consistently higher for behaviour (11.0-19.9%) than other (7.1-14.0%) disorders. Conclusions Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.
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