期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 199, 期 5, 页码 391-397出版社
ROYAL COLLEGE OF PSYCHIATRISTS
DOI: 10.1192/bjp.bp.110.084178
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-
类别
资金
- Canadian Institutes of Health Research [MOP-36429]
- McGill University
- McGill University Health Centre
Background Low serotonin transmission is thought to increase susceptibility to a wide range of substance use disorders and impulsive traits. Aims To investigate the effects of lowered serotonin on cocaine-induced (1.0 mg/kg cocaine, self-administered intranasally) dopamine responses and drug craving. Method In non-dependent cocaine users, serotonin transmission was reduced using the acute tryptophan depletion method. Striatal dopamine responses were measured using positron emission tomography with [C-11]raclopride. Results Acute tryptophan depletion increased drug craving and striatal dopamine responses to cocaine. These acute tryptophan depletion-induced increases did not occur in the absence of cocaine. Conclusions The results suggest that low serotonin transmission can increase dopaminergic and appetitive responses to cocaine. These findings might identify a mechanism by which individuals with low serotonin are at elevated risk for both substance use disorders and comorbid conditions.
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