期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 197, 期 6, 页码 448-455出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.110.077289
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- Dutch ministry of Health, welfare, and Sports (ZonMw) [100-002-017]
Background Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. Method Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). Results Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d=0.48) and medication adherence (Cohen's d=0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P=0.053). Symptoms and quality of life did not improve. Conclusions Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission.
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