期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 197, 期 5, 页码 378-385出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.110.080499
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资金
- Bristol-Myers Squibb
- Eli Lilly Company
- GlaxoSmithKline
- Johnson & Johnson Pharmaceuticals
- Ortho-McNeil Pharmaceuticals
- Pfizer
- Sanofi-Aventis
- United States National Institute of Mental Health [R01MH070884, R01-MH059575, RO1-MH61905]
- John D. and Catherine T. MacArthur Foundation
- Pfizer Foundation
- US Public Health Service [R13-MH066849, R01-MH069864, R01 DA016558]
- Fogarty International Center [FIRCA R03-TW006481]
- Pan American Health Organization (PAHO)
- Eli Lilly & Company Foundation
- Shire
- State of Sao Paulo Research Foundation (FAPESP) [03/00204-3]
- Ministry of Health
- National Center for Public Health Protection
- Shenzhen Bureau of Health
- Shenzhen Bureau of Science, Technology, and Information
- Ministry of Social Protection
- European Commission [QLG5-1999-01042, SANCO 2004123]
- Piedmont Region (Italy)
- Fondo de Investigacion Sanitaria
- Instituto de Salad Carlos III, Spain [FIS 00/0028]
- Ministerio de Ciencia y Tecnologia, Spain [SAF 2000-158-CE]
- Departament de Salut
- Generalitat de Catalunya, Spain
- Instituto de Salud Carlos III [CIBER CB06/02/0046, RETICS RD06/0011 REM-TAP]
- WHO (India)
- Japanese and European Funds through United Nations Development Group Iraq Trust Fund (UNDG ITF)
- Israel National Institute for Health Policy and Health Services Research
- National Insurance Institute of Israel
- Japan Ministry of Health, Labour and Welfare [H13-SHOGAI-023, H14-TOKUBETSU-026, H16-KOKORO-013]
- Lebanese Ministry of Public Health
- WHO (Lebanon)
- Fogarty International
- Act for Lebanon
- Janssen Cilag
- Eli Lilly
- Roche
- Novartis
- National Institute of Psychiatry Ramon de la Fuente [INPRFMDIES 4280]
- National Council on Science and Technology [CONACyT-G30544- H]
- New Zealand Ministry of Health
- Alcohol Advisory Council
- Health Research Council
- WHO (Geneva)
- WHO (Nigeria)
- Federal Ministry of Health, Abuja, Nigeria
- Ministry of Public Health
- National Institute of Drug Abuse
- South African Department of Health
- University of Michigan
- National Institute of Mental Health [U01-MH60220]
- Robert Wood Johnson Foundation (RWJF) [044708]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/00204-3] Funding Source: FAPESP
Background Although significant associations of childhood adversities with adult mental disorders are widely documented, most studies focus on single childhood adversities predicting single disorders. Aims To examine joint associations of 12 childhood adversities with first onset of 20 DSM-IV disorders in World Mental Health (WMH) Surveys in 21 countries. Method Nationally or regionally representative surveys of 51 945 adults assessed childhood adversities and lifetime DSM-IV disorders with the WHO Composite International Diagnostic Interview (CIDI). Results Childhood adversities were highly prevalent and interrelated. Childhood adversities associated with maladaptive family functioning (e.g. parental mental illness, child abuse, neglect) were the strongest predictors of disorders. Co-occurring childhood adversities associated with maladaptive family functioning had significant subadditive predictive associations and little specificity across disorders. Childhood adversities account for 29.8% of all disorders across countries. Conclusions Childhood adversities have strong associations with all classes of disorders at all life-course stages in all groups of WMH countries. Long-term associations imply the existence of as-yet undetermined mediators.
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