期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 192, 期 1, 页码 19-24出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.036921
关键词
-
类别
资金
- MRC [G0400061] Funding Source: UKRI
- National Institute for Health Research [RP-PG-0606-1045] Funding Source: researchfish
- Medical Research Council [G0400061] Funding Source: Medline
- Department of Health [RP-PG-0606-1045] Funding Source: Medline
Background Lack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder. Aims To investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals. Method We used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls. Results When rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview. Conclusions In people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour. Declaration of interest None. Funding detailed in Acknowledgements.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据