期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 193, 期 5, 页码 422-423出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.041467
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- Netherlands organization for Health Research and Development ZonMw [908-02-123]
To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process. Declaration of interest None. Funding detailed in Acknowledgements.
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