期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 193, 期 5, 页码 383-388出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.045427
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资金
- Instituto Carlos III (Spanish ministry of Health) [P1041635, P1041783, P1041779, P1041758, P1041761, P1041791, P1041766, PI041782]
- The Spanish Psychiatric Genetics and Genotyping network [G03/184]
- Spanish mental Health Network
Background Polymorphic variations in the serotonin transporter gene (5-HTT) moderate the depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction in brain tryptophan availability, thus polymorphic variations in 5-HTT may play a similar role in the post-partum period. Aims To study the role of 5-HTT polymorphic variations in mood changes after delivery. Method One thousand, eight hundred and four depression-free Spanish women were studied post-partum. We evaluated depressive symptoms at 2-3 days, 8 weeks and 32 weeks post-partum. We used diagnostic interview to confirm major depression for all probable cases. Based on two polymorphisms of 5-HTT (5-HTTLPR and STin2 VNTR), three genotype combinations were created to reflect different levels of 5-HTT expression. Results One hundred and seventy-three women (12.7%) experienced major depression during the 32-week post-partum period, Depressive symptoms were associated with the high-expression 5-HTT genotypes in a dose-response fashion at 8 weeks post-partum, but not at 32 weeks. Conclusions High-expression 5-HTT genotypes may render women more vulnerable to depressive symptoms after childbirth. Declaration of interest None. Funding detailed in Acknowledgements.
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