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Stephen P. H. Alexander et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Identification through high-throughput screening of 4′-methoxyflavone and 3′,4′-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
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BRITISH JOURNAL OF PHARMACOLOGY (2013)
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Jana Krietsch et al.
MOLECULAR ASPECTS OF MEDICINE (2013)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon et al.
CELL (2012)
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
L. Galluzzi et al.
CELL DEATH AND DIFFERENTIATION (2012)
Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation
Irina F. Sevrioukova
ANTIOXIDANTS & REDOX SIGNALING (2011)
Activation of Cell Death Mediated by Apoptosis-Inducing Factor Due to the Absence of Poly(ADP-ribose) Glycohydrolase
Yiran Zhou et al.
BIOCHEMISTRY (2011)
Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
Shaida A. Andrabi et al.
NATURE MEDICINE (2011)
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage
Ho Chul Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)
Yingfei Wang et al.
SCIENCE SIGNALING (2011)
Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia
Zhenfeng Xu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2010)
Multifaceted deaths orchestrated by mitochondria in neurones
Phillip Nagley et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
Poly(ADP-Ribose) Metabolism in Brain and Its Role in Ischemia Pathology
Robert Piotr Strosznajder et al.
MOLECULAR NEUROBIOLOGY (2010)
Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake
Eri Suzuki et al.
LIFE SCIENCES (2010)
PARP inhibition: PARP1 and beyond
Michele Rouleau et al.
NATURE REVIEWS CANCER (2010)
Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release
Seong-Woon Yu et al.
ASN NEURO (2009)
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
G. Kroemer et al.
CELL DEATH AND DIFFERENTIATION (2009)
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke
Mike Yuan et al.
EXPERIMENTAL NEUROLOGY (2009)
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
Yingfei Wang et al.
EXPERIMENTAL NEUROLOGY (2009)
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases
Andreina Peralta-Leal et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Parthanatos, a messenger of death
Karen Kate David et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Critical Role of Poly(ADP-Ribose) Polymerase-1 in Modulating the Mode of Cell Death Caused by Continuous Oxidative Stress
Young-Ok Son et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)
Yingfei Wang et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Poly (ADP-ribose) Polymerase-1-inhibiting Flavonoids Attenuate Cytokine Release in Blood from Male Patients with Chronic Obstructive Pulmonary Disease or Type 2 Diabetes
Antje R. Weseler et al.
JOURNAL OF NUTRITION (2009)
Genome-wide silencing in Drosophila captures conserved apoptotic effectors
Su Kit Chew et al.
NATURE (2009)
Selective Down-Regulation of Nuclear Poly(ADP-Ribose) Glycohydrolase
David M. Burns et al.
PLOS ONE (2009)
Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease
Pal Pacher et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Mitochondrial and Nuclear Cross Talk in Cell Death Parthanatos
Shaida A. Andrabi et al.
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2
Marlene T. Mathews et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit?
Elgin Yap et al.
BRAIN RESEARCH (2008)
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death
S. Landshamer et al.
CELL DEATH AND DIFFERENTIATION (2008)
On the way to selective PARP-2 inhibitors. Design, synthesis, and prelimionary evaluation of a series of isoquinolinone derivatives
Roberto Pellicciari et al.
CHEMMEDCHEM (2008)
Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis:: Potential role of PARP inhibitors in cancer treatment
Andreina Peralta-Leal et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2008)
Poly(ADP-ribose) polymerase: a new therapeutic target?
Domokos Geroe et al.
CURRENT OPINION IN ANESTHESIOLOGY (2008)
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
Nicholas C. Turner et al.
EMBO JOURNAL (2008)
Oxidative stress in neurodegeneration and available means of protection
Amos Akintayo Fatokun et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors
Tobias Eltze et al.
MOLECULAR PHARMACOLOGY (2008)
Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
Jean-Philippe Gagne et al.
NUCLEIC ACIDS RESEARCH (2008)
Advances in neuronal cell death 2007
Maged M. Harraz et al.
STROKE (2008)
Therapeutic potential of AIF-mediated caspase-independent programmed cell death
Hans K. Lorenzo et al.
DRUG RESISTANCE UPDATES (2007)
Flavone as PARP-1 inhibitor: Its effect on lipopolysaccharide induced gene-expression
Liesbeth Geraets et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes
J. Andrew Pospisilik et al.
CELL (2007)
PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells
Chantal Ethier et al.
APOPTOSIS (2007)
N-Methyl-N′-Nitro-N-Nitrosoguanidine activates multiple cell death mechanisms in human fibroblasts
Michael W. Lee et al.
DNA AND CELL BIOLOGY (2007)
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
Guodong Cao et al.
JOURNAL OF NEUROSCIENCE (2007)
Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
Changlian Zhu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity
Ralph G. Meyer et al.
EXPERIMENTAL CELL RESEARCH (2007)
Pharmacological inhibition of PARP-1 reduces α-synucleinand MPP+-induced cytotoxicity in Parkinson's disease in vitro models
Tiago Fleming Outeiro et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Poly(ADP-ribose) polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat
Jeong Hyun Lee et al.
BRAIN RESEARCH (2007)
The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury
Christian Maier et al.
INTENSIVE CARE MEDICINE (2007)
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia
C. Zhu et al.
CELL DEATH AND DIFFERENTIATION (2007)
Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion
Aaron M. Hamby et al.
STROKE (2007)
Role of Poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: The therapeutic potential of PARP inhibitors
Pal Pacher et al.
CARDIOVASCULAR DRUG REVIEWS (2007)
Poly(ADP-ribose) (PAR) polymer is a death signal
Shaida A. Andrabi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
Seong-Woon Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1
Claudia Keil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cell death in the nervous system
Dale E. Bredesen et al.
NATURE (2006)
Genotype-dependent priming to self- and xeno-cannibalism in heterozygous and homozygous lymphoblasts from patients with Huntington's disease
Elisabetta Mormone et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity
Cecile Delettre et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
EndoG is dispensable in embryogenesis and apoptosis
K. K. David et al.
CELL DEATH AND DIFFERENTIATION (2006)
Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death
Christian Blenn et al.
BIOCHEMICAL JOURNAL (2006)
Poly( ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice
Andrea Cozzi et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2006)
AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer
C Delettre et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling
J Ishida et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage
JF Haince et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)
Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy
N Joza et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia
C Culmsee et al.
JOURNAL OF NEUROSCIENCE (2005)
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-Ribose) polymerase
N McCabe et al.
CANCER BIOLOGY & THERAPY (2005)
Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone
PG Jagtap et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1
TYJ Yeh et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2005)
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications
C Szabó
PHARMACOLOGICAL RESEARCH (2005)
Clinical perspectives of PARP inhibitors
G Graziani et al.
PHARMACOLOGICAL RESEARCH (2005)
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
P Jagtap et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
HE Bryant et al.
NATURE (2005)
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer et al.
NATURE (2005)
Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space
H Otera et al.
EMBO JOURNAL (2005)
Expression pattern of apoptosis-related markers in Huntington's disease
JC Vis et al.
ACTA NEUROPATHOLOGICA (2005)
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors
A Iwashita et al.
FEBS LETTERS (2005)
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms
ECC Cheung et al.
JOURNAL OF NEUROSCIENCE (2005)
Poly (ADP-Ribose) Polymerase Inhibitors as Potential Therapeutic Agents in Stroke and Neurotrauma
Katalin Komjati et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
The monofunctional alkylating agent N-methyl-N '-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways
WJ Kim et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Role of AIF in caspase-dependent and caspase-independent cell death
SP Cregan et al.
ONCOGENE (2004)
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis
C Candé et al.
ONCOGENE (2004)
Widespread increased expression of the DNA repair enzyme PARP in brain in ALS
SH Kim et al.
NEUROLOGY (2004)
Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster
S Hanai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals
SH Koh et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
The expression of PARP, NF-κB and parvalbumin is increased in Parkinson disease
J Soós et al.
NEUROREPORT (2004)
A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia
A Iwashita et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality
DW Koh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Deadly conversations: Nuclear-mitochondrial cross-talk
VL Dawson et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2004)
Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments
ML Meyer-Ficca et al.
EXPERIMENTAL CELL RESEARCH (2004)
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death
HM Wang et al.
JOURNAL OF NEUROSCIENCE (2004)
Differential role of poly(ADP-ribose) polymerase-1 in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro
E Meli et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2004)
Alteration of poly(ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases
ME Bonicalzi et al.
BIOLOGY OF THE CELL (2003)
3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice
JY Couturier et al.
EXPERIMENTAL NEUROLOGY (2003)
Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia - Its role in brain edema and cell death
RP Strosznajder et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2003)
PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients
SH Kim et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2003)
Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity
SW Yu et al.
NEUROBIOLOGY OF DISEASE (2003)
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
D Arnoult et al.
JOURNAL OF CELL BIOLOGY (2002)
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans
XC Wang et al.
SCIENCE (2002)
The harlequin mouse mutation down-regulates apoptosis-inducing factor
JA Klein et al.
NATURE (2002)
DNA binding is required for the apoptogenic action of apoptosis inducing factor
H Ye et al.
NATURE STRUCTURAL BIOLOGY (2002)
The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
L Virág et al.
PHARMACOLOGICAL REVIEWS (2002)
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
SP Cregan et al.
JOURNAL OF CELL BIOLOGY (2002)
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
SW Yu et al.
SCIENCE (2002)
The pharmacological manipulation of glutamate receptors and neuroprotection
TW Stone et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
The crystal structure of the mouse apoptosis-inducing factor AIF
MJ Maté et al.
NATURE STRUCTURAL BIOLOGY (2002)
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: Differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors
L Giovannelli et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)
Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery
S Goto et al.
STROKE (2002)
Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase
U Koedel et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)
Impairment of the neuronal dopamine transporter activity in MPP+-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors
S Barc et al.
NEUROSCIENCE LETTERS (2001)
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
JG Mabley et al.
INFLAMMATION RESEARCH (2001)
Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment
YC Ding et al.
BRAIN RESEARCH (2001)
Intracellular delivery of proteins with a new lipid-mediated delivery system
O Zelphati et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia
F Moroni et al.
CELL DEATH AND DIFFERENTIATION (2001)
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism
L Davidovic et al.
EXPERIMENTAL CELL RESEARCH (2001)
Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats
MC LaPlaca et al.
JOURNAL OF NEUROTRAUMA (2001)
The world according to PARP
S Smith
TRENDS IN BIOCHEMICAL SCIENCES (2001)
Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor
M Loeffler et al.
FASEB JOURNAL (2001)
Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes
M Kanai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
S Shall et al.
MUTATION RESEARCH-DNA REPAIR (2000)
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain
S Ducrocq et al.
JOURNAL OF NEUROCHEMISTRY (2000)
The neuroprotective effect of cerebral poly(ADP-ribose) polymerase inhibition in a rat model of global ischemia
K Plaschke et al.
NEUROSCIENCE LETTERS (2000)
Activation of poly(ADP-Ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia
T Nagayama et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Neuronal death in brain infarcts in man
S Love et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2000)