期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 171, 期 3, 页码 555-566出版社
WILEY
DOI: 10.1111/bph.12279
关键词
heart; gender; hypertrophy; cardiac failure
资金
- CNRS
- Univ-Paris Diderot
- GRRC (Groupe de Reflexion sur la Recherche Cardiovasculaire)
- SFHTA
Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular pathophysiology have long been known, the sex-specific mechanisms mediating these processes have been further elucidated over recent years. This review aims at analysing the sex-based differences in cardiac structure and function in adult mammals, and the sex-based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex-based difference is a variable that should be dealt with, not only in basic science or clinical research, but also with regards to therapeutic approaches.
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