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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
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The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ-δ Opioid Receptors
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ACS CHEMICAL NEUROSCIENCE (2012)
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Heterodimerization of human apelin and kappa opioid receptors: Roles in signal transduction
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CELLULAR SIGNALLING (2012)
6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
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NATURE (2012)
Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5
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ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Receptor Heteromerization Expands the Repertoire of Cannabinoid Signaling in Rodent Neurons
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Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain
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PLOS ONE (2012)
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers
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ACS MEDICINAL CHEMISTRY LETTERS (2012)
Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons
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Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands
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BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids
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CELL (2011)
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EUROPEAN NEUROPSYCHOPHARMACOLOGY (2011)
Protein Kinase Cζ Mediates μ-Opioid Receptor-induced Cross-desensitization of Chemokine Receptor CCR5
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Heteromerization of the μ- and δ-Opioid Receptors Produces Ligand-Biased Antagonism and Alters μ-Receptor Trafficking
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding
Ivone Gomes et al.
MOLECULAR PHARMACOLOGY (2011)
Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation
Shao-Qiu He et al.
NEURON (2011)
N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers
Ajay S. Yekkirala et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Heterodimerization of ORL1 and Opioid Receptors and Its Consequences for N-type Calcium Channel Regulation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Formation of μ-/κ-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration
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SCIENCE SIGNALING (2010)
p38 MAPK and β-Arrestin 2 Mediate Functional Interactions between Endogenous μ-Opioid and α2A-Adrenergic Receptors in Neurons
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Protein Kinase C Mediates the Synergistic Interaction Between Agonists Acting at α2-Adrenergic and Delta-Opioid Receptors in Spinal Cord
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JOURNAL OF NEUROSCIENCE (2009)
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NATURE CHEMICAL BIOLOGY (2009)
Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the μ-opioid receptor
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Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation
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μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB1 Receptor: Electrophysiological and FRET Assay Analysis
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JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)
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NATURE CHEMICAL BIOLOGY (2008)
Cell surface targeting of μ-δ opioid receptor heterodirners by RTP4
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Trafficking of preassembled opioid μ-δ heterooligomer-Gz signaling complexes to the plasma membrane:: Coregulation by agonists
Ahmed Hasbi et al.
BIOCHEMISTRY (2007)
Receptor heterodimerization leads to a switch in signaling:: β-arrestin2-mediated ERK activation by μ-δ opioid receptor heterodimers
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FASEB JOURNAL (2007)
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EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
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Ming-He Huang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for δ/μ opioid receptor agonists and neurokinin-1 receptor antagonists
Takashi Yamamoto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
μ opioid and CB1 cannabinoid receptor interactions:: reciprocal inhibition of receptor signaling and neuritogenesis
Carl Rios et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Differential effects of μ-opioid, δ-opioid and κ-opioid receptor agonists on dopamine receptor agonist-induced climbing behavior in mice
Shinobu Ito et al.
BEHAVIOURAL PHARMACOLOGY (2006)
Simultaneous activation of the δ opioid receptor (δOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits δOR signaling
Andreas Breit et al.
MOLECULAR PHARMACOLOGY (2006)
Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons
L. M. Ambrose et al.
NEUROSCIENCE LETTERS (2006)
Role of 5-HT1A and 5-HT2 receptors of dorsal and median raphe nucleus in tolerance to morphine analgesia in rats
ARM Nayebi et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
DJ Daniels et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of μ and δ opioid receptor hetero-oligomers
T Fan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
κ- and δ-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice
L Urigüen et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
M Waldhoer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer
DX Wang et al.
MOLECULAR PHARMACOLOGY (2005)
Heterodimerization of μ- and δ-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
PY Law et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Heterodimerization of opioid receptor-like 1 and μ-opioid receptors impairs the potency of μ receptor agonist
HL Wang et al.
JOURNAL OF NEUROCHEMISTRY (2005)
A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia
I Gomes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Synergistic interactions between cannabinoid and opioid analgesics
DL Cichewicz
LIFE SCIENCES (2004)
Heterodimerization and cross-desensitization between the μ-opioid receptor and the chemokine CCR5 receptor
CG Chen et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Hetero-oligomerization between β2-and β3-adrenergic receptors generates a β-adrenergic signaling unit with distinct functional properties
A Breit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hetero-oligomers of α2A-adrenergic and μ-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles
YQ Zhang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
A bivalent ligand (KDN-21) reveals spinal δ and κ opioid receptors are organized as heterodimers that give rise to δ1 and κ2 phenotypes.: Selective targeting of δ-κ heterodimers
RG Bhushan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Interactions between δ opioid receptors and α2A-adrenoceptors
C Rios et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2004)
Sensory central neuron-specific receptor activation elicits and peripheral nociceptive effects in rats
E Grazzini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Heterodimerization of substance P and μ-opioid receptors regulates receptor trafficking and resensitization
M Pfeiffer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Functional interactions between μ opioid and α2A-adrenergic receptors
BA Jordan et al.
MOLECULAR PHARMACOLOGY (2003)
Adenosine A2A-dopamine D2 receptor-receptor heteromerization -: Qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
M Canals et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPγS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice
F Berrendero et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
DPDPE-UK14,304 synergy is retained in mu opioid receptor knockout mice
XH Guo et al.
PAIN (2003)
Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis
S Terrillon et al.
MOLECULAR ENDOCRINOLOGY (2003)
Coexpression of delta-opioid receptors with mu receptors in GH(3) cells changes the functional response to mu agonists from inhibitory to excitatory
AC Charles et al.
MOLECULAR PHARMACOLOGY (2003)
Interactions of opioid and chemokine receptors:: Oligomerization of mu, kappa, and delta with CCR5 on immune cells
S Suzuki et al.
EXPERIMENTAL CELL RESEARCH (2002)
Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype
YX Pan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol
F Berrendero et al.
PSYCHOPHARMACOLOGY (2002)
Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences
D Ramsay et al.
BIOCHEMICAL JOURNAL (2002)
Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization
M Pfeiffer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Regulation of opioid receptor trafficking and morphine tolerance by receptor oligornerization
L He et al.
CELL (2002)
Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs
PMC Lembo et al.
NATURE NEUROSCIENCE (2002)
alpha(2C)-adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy
CA Fairbanks et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Supersensitivity of 5-HT1A-autoreceptors and alpha(2)-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats
A Sastre-Coll et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2002)
Synergistic μ-opioid and 5-HT1A presynaptic inhibition of GABA release in rat periaqueductal gray neurons
K Kishimoto et al.
NEUROPHARMACOLOGY (2001)
Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
A Reaux et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Expression of 5-HT1A receptor mRNA in rat dorsal raphe nucleus and ventrolateral periaqueductal gray neurons after peripheral inflammation
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NEUROREPORT (2000)
Morphine induces gene expression of CCR5 in human CEM x174 lymphocytes
T Miyagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Oligomerization of μ- and δ-opioid receptors -: Generation of novel functional properties
SR George et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia
A Rizzi et al.
NEUROREPORT (2000)
Dopamine-opioid interactions in the rat striatum: a modulatory role for dopamine D-1 receptors in delta opioid receptor-mediated signal transduction
EM Unterwald et al.
NEUROPHARMACOLOGY (2000)
Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice
CA Fairbanks et al.
PAIN (2000)
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