相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2
Nicola Laurieri et al.
PLOS ONE (2014)
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity
Areej Abuhammad et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)
Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
Elizabeth Fullam et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Full-Gene-Sequencing Analysis of N-Acetyltransferase-2 in an Adult Indian Population
Ashwini V. Tilak et al.
GENETIC TESTING AND MOLECULAR BIOMARKERS (2013)
Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India
Vinod H. Gupta et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)
How Personalized Medicine Became Genetic, and Racial: Werner Kalow and the Formations of Pharmacogenetics
David S. Jones
JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES (2013)
A practical guide to monitoring for adverse drug reactions during antihypertensive drug therapy
Sarah E. McDowell et al.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2013)
A Novel Color Change Mechanism for Breast Cancer Biomarker Detection: Naphthoquinones as Specific Ligands of Human Arylamine N-Acetyltransferase 1
Nicola Laurieri et al.
PLOS ONE (2013)
Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice
Kim S. Sugamori et al.
CANCER LETTERS (2012)
Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct
Lori M. Millner et al.
CARCINOGENESIS (2012)
The Differential Effect of NAT2 Variant Alleles Permits Refinement in Phenotype Inference and Identifies a Very Slow Acetylation Genotype
Jhon D. Ruiz et al.
PLOS ONE (2012)
N-Acetyltransferase Polymorphism and Risk of Colorectal Adenoma and Cancer: A Pooled Analysis of Variations from 59 Studies
Jinxin Liu et al.
PLOS ONE (2012)
Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages
Areej Abuhammad et al.
PLOS ONE (2012)
Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
David W. Hein et al.
PHARMACOGENOMICS (2012)
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
Sarah M. Batt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Phenotype of the Most Common Slow Acetylator Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
Lori M. Millner et al.
DRUG METABOLISM AND DISPOSITION (2012)
Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker
Ida Johansson et al.
BREAST CANCER RESEARCH (2012)
Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development
Neville J. Butcher et al.
PHARMACOLOGICAL REVIEWS (2012)
Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
Elizabeth Fullam et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Novel Small-Molecule Inhibitors of Arylamine N-Acetyltransferases: Drug Discovery by High Throughput Screening
Isaac M. Westwood et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2011)
The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes
Benjamin Pluvinage et al.
FEBS LETTERS (2011)
RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition
Jacky M. Tiang et al.
PLOS ONE (2011)
Arylamine N-Acetyltransferase 2 (NAT2) Genetic Diversity and Traditional Subsistence: A Worldwide Population Survey
Audrey Sabbagh et al.
PLOS ONE (2011)
Effects of Single Nucleotide Polymorphisms on Human N-Acetyltransferase 2 Structure and Dynamics by Molecular Dynamics Simulation
M. Rajasekaran et al.
PLOS ONE (2011)
Conference Scene: Pharmacogenomics, biochemistry, toxicology, microbiology and cancer research in one go
Fernando Rodrigues-Lima et al.
PHARMACOGENOMICS (2011)
Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents
Areej Abuhammad et al.
PROTEIN EXPRESSION AND PURIFICATION (2011)
Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells
Jacky M. Tiang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1
Neville J. Butcher et al.
CARCINOGENESIS (2010)
Characterisation of CpG methylation in the upstream control region of mouse Nat2: Evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism
Larissa Wakefield et al.
GENE (2010)
Genes, Environment, and Orofacial Clefting: N-Acetyltransferase and Folic Acid
Robert P. Erickson
JOURNAL OF CRANIOFACIAL SURGERY (2010)
A Novel Mechanism for Azoreduction
Ali Ryan et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Codominant Expression of N-Acetylation and O-Acetylation Activities Catalyzed by N-Acetyltransferase 2 in Human Hepatocytes
Mark A. Doll et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Small Molecule Colorimetric Probes for Specific Detection of Human Arylamine N-Acetyltransferase 1, a Potential Breast Cancer Biomarker
Nicola Laurieri et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases
Pedro J. Ballester et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (2010)
N-acetyltransferase 2 activity and folate levels
Wen Cao et al.
LIFE SCIENCES (2010)
Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site
Areej M. Abuhammad et al.
PROTEIN & CELL (2010)
Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases
Ali Ryan et al.
PROTEIN & CELL (2010)
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars
Isaac M. Westwood et al.
PROTEIN & CELL (2010)
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis
Nathan A. Lack et al.
BIOCHEMICAL JOURNAL (2009)
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2
Angela J. Russell et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Isoform-Selective Inactivation of Human Arylamine N-Acetyltransferases by Reactive Metabolites of Carcinogenic Arylamines
Li Liu et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine
David W. Hein
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Comparison of the Arylamine N-Acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis
Elizabeth Fullam et al.
PROTEIN JOURNAL (2009)
Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis
Katherine C. Yam et al.
PLOS PATHOGENS (2009)
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1
Akane Kawamura et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis
Alison L. Sikora et al.
BIOCHEMISTRY (2008)
Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system
Larissa Wakefield et al.
BIOMARKERS (2008)
Arylamine N-acetyltransferases in prokaryotic and eukaryotic genomes: A survey of public databases
Eirini Vagena et al.
CURRENT DRUG METABOLISM (2008)
Arylamine N-acetyltransferases in mycobacteria
Edith Sim et al.
CURRENT DRUG METABOLISM (2008)
Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1
Jason M. Walraven et al.
DRUG METABOLISM REVIEWS (2008)
Arylamine N-acetyltransferases: From structure to function
Edith Sim et al.
DRUG METABOLISM REVIEWS (2008)
Arylamine N-acetyltransferase I expression in breast cancer cell lines:: A potential marker in estrogen receptor-positive tumors
Larissa Wakefield et al.
GENES CHROMOSOMES & CANCER (2008)
Divergence of cofactor recognition across evolution:: Coenzyme a binding in a prokaryotic arylamine N-acetyltransferase
Elizabeth Fullam et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Confirmation of the role of n-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts
Robert P. Erickson et al.
MOLECULAR REPRODUCTION AND DEVELOPMENT (2008)
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Lambertus A. Kiemeney et al.
NATURE GENETICS (2008)
Changes in consensus arylamine N-acetyltransferase gene nomenclature
David W. Hein et al.
PHARMACOGENETICS AND GENOMICS (2008)
Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms
Edith Sim et al.
TOXICOLOGY (2008)
Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism
Larissa Wakefield et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa
Chan-Ju Wang et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases
Hong Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse
K. S. Sugamori et al.
DRUG METABOLISM AND DISPOSITION (2007)
Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
Vukani Eliya Madikane et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues
Anwar Husain et al.
DRUG METABOLISM AND DISPOSITION (2007)
Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene
Larissa Wakefield et al.
MAMMALIAN GENOME (2007)
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
Robert Van der Geize et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells
Neville J. Butcher et al.
CANCER RESEARCH (2007)
Arylamine N-acetyltransferases
Edith Sim et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)
Arylamine N-acetyltransferase I
Rodney F. Minchin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice
Jennifer A. Loehle et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity
Naixia Zhang et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation
Fen Liu et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Loss of function polymorphisms in NAT1 protect against spina bifida
Liselotte E. Jensen et al.
HUMAN GENETICS (2006)
Sub-Saharan African Coding Sequence Variation and Haplotype Diversity at the NAT2 Gene
Etienne Patin et al.
HUMAN MUTATION (2006)
Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1
David F. Barker et al.
PHARMACOGENETICS AND GENOMICS (2006)
Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes
E Patin et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG
MC Anderton et al.
MOLECULAR MICROBIOLOGY (2006)
Structure and mechanism of arylamine N-acetyltransferases
I. M. Westwood et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Mutational and expression analysis of tbnat and its response to isoniazid
C Sholto-Douglas-Vernon et al.
JOURNAL OF MEDICAL MICROBIOLOGY (2005)
Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines
J Sandy et al.
BIOCHEMICAL JOURNAL (2005)
The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida
LE Jensen et al.
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY (2005)
Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts
S Boukouvala et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2005)
Arylamine N-acetyltransferase 2 expression in the developing heart
L Wakefield et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2005)
Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis
J Sandy et al.
PROTEIN SCIENCE (2005)
Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1
HQ Wang et al.
PROTEIN JOURNAL (2005)
Only low levels of exogenous N-acetyltransferase can be achieved in transgenic mice
W Cao et al.
PHARMACOGENOMICS JOURNAL (2005)
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase
IM Westwood et al.
BIOCHEMICAL JOURNAL (2005)
Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening
A Kawamura et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1)
A Husain et al.
PHARMACOGENETICS (2004)
Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies
HQ Wang et al.
BIOCHEMISTRY (2004)
Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for Orofacial clefts
EJ Lammer et al.
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY (2004)
Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine -: A mechanism for the slow acetylator phenotype and substrate-dependent down-regulation
NJ Butcher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target
S Bhakta et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma
I Bieche et al.
BREAST CANCER RESEARCH (2004)
Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice
S Boukouvala et al.
BIOCHEMICAL JOURNAL (2003)
Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs)
EW Brooke et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice
KS Sugamori et al.
MOLECULAR PHARMACOLOGY (2003)
Arylamine N-acetyltransferases: a pharmacogenomic approach to drug metabolism and endogenous function
E Sim et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases
EW Brooke et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium
R Delgoda et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2003)
Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene
VA Cornish et al.
PHARMACOGENOMICS JOURNAL (2003)
Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis
DW Hein
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2002)
Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice
S Boukouvala et al.
PHARMACOGENETICS (2002)
The structure of arylamine N-acetyltransferase from mycobacterium smegmatis -: An enzyme which inactivates the anti-tubercular drug, Isoniazid
J Sandy et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity
A Mushtaq et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
3D model of human arylamine N-acetyltransferase 2:: Structural basis of the slow acetylator phenotype of the R64Q variant and analysis of the active-site loop
F Rodrigues-Lima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Complement and systemic lupus erythematosus
Mark J. Walport
ARTHRITIS RESEARCH & THERAPY (2002)
Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis
M Payton et al.
MICROBIOLOGY-SGM (2001)
Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism
AM Upton et al.
MOLECULAR MICROBIOLOGY (2001)
N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast
JA Williams et al.
PHARMACOGENETICS (2001)
Identification and functional characterization of arylamine N-acetyltransferases in eubacteria:: Evidence for highly selective acetylation of 5-aminosalicylic acid
C Deloménie et al.
JOURNAL OF BACTERIOLOGY (2001)
Eubacterial arylamine N-acetyltransferases -: identification and comparison of 18 members of the protein family with conserved active site cysteine, histidine and aspartate residues
M Payton et al.
MICROBIOLOGY-SGM (2001)
Ludwig Rehn (1849-1930) - Pioneering findings on the aetiology of bladder tumours
H Dietrich et al.
WORLD JOURNAL OF UROLOGY (2001)
Placental arylamine N-acetyltransferase type 1:: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy
A Upton et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2000)
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity
M Pirmohamed et al.
PHARMACOGENETICS (2000)
An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes
E Sim et al.
HUMAN MOLECULAR GENETICS (2000)
Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2
GH Goodfellow et al.
BIOCHEMICAL JOURNAL (2000)
Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos
VA Smelt et al.
HUMAN MOLECULAR GENETICS (2000)
Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2
G Fakis et al.
CYTOGENETICS AND CELL GENETICS (2000)