4.7 Review

Targeting the histone orthography of cancer: drugs for writers, erasers and readers

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Genetics & Heredity

Cancer genomics identifies disrupted epigenetic genes

Laia Simo-Riudalbas et al.

HUMAN GENETICS (2014)

Review Medicine, Research & Experimental

New and emerging HDAC inhibitors for cancer treatment

Alison C. West et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

Toni Pfaffeneder et al.

NATURE CHEMICAL BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

Targeting bromodomains: epigenetic readers of lysine acetylation

Panagis Filippakopoulos et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Adam J. Pawson et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis

M. Rodriguez-Paredes et al.

ONCOGENE (2014)

Article Biochemistry & Molecular Biology

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Kyle D. Konze et al.

ACS CHEMICAL BIOLOGY (2013)

Article Hematology

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Scott R. Daigle et al.

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: ENZYMES

Stephen P. H. Alexander et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Review Oncology

In focus: MLL-rearranged leukemia

J. de Boer et al.

LEUKEMIA (2013)

Article Biochemistry & Molecular Biology

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

Lindsey I. James et al.

NATURE CHEMICAL BIOLOGY (2013)

Letter Biochemistry & Molecular Biology

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

Fanny L. Cherblanc et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Multidisciplinary Sciences

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Sarah K. Knutson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Pharmacology & Pharmacy

Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview

Mahadevappa Hemshekhar et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)

Article Biochemistry & Molecular Biology

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

Panagis Filippakopoulos et al.

Review Cell Biology

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

Omar Khan et al.

IMMUNOLOGY AND CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett et al.

NATURE (2012)

Article Multidisciplinary Sciences

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe et al.

NATURE (2012)

Article Multidisciplinary Sciences

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Editorial Material Multidisciplinary Sciences

Genetic Events That Shape the Cancer Epigenome

Russell J. H. Ryan et al.

SCIENCE (2012)

Article Chemistry, Medicinal

Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

Chris J. Vickers et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Multidisciplinary Sciences

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Wenyu Yu et al.

NATURE COMMUNICATIONS (2012)

Review Oncology

The role of mutations in epigenetic regulators in myeloid malignancies

Alan H. Shih et al.

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Inhibitors of histone demethylases

Brian Lohse et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Review Hematology

Peripheral T-cell lymphoma

Francine M. Foss et al.

Article Biochemistry & Molecular Biology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake E. Delmore et al.

Review Cell Biology

Regulation of chromatin by histone modifications

Andrew J. Bannister et al.

CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

Chemogenetic Analysis of Human Protein Methyltransferases

Victoria M. Richon et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2011)

Article Chemistry, Medicinal

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

Kai-Hsuan Chang et al.

CHEMMEDCHEM (2011)

Review Oncology

Hypomethylating Agents and Other Novel Strategies in Myelodysplastic Syndromes

Guillermo Garcia-Manero et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Chemistry, Medicinal

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

J. Martin Herold et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Masoud Vedadi et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Genetics & Heredity

Analysis of the coding genome of diffuse large B-cell lymphoma

Laura Pasqualucci et al.

NATURE GENETICS (2011)

Article Multidisciplinary Sciences

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Jennifer A. Mertz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Oncology

A decade of exploring the cancer epigenome - biological and translational implications

Stephen B. Baylin et al.

NATURE REVIEWS CANCER (2011)

Review Biochemistry & Molecular Biology

Oxidation of amines by flavoproteins

Paul F. Fitzpatrick

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Review Biochemistry & Molecular Biology

Sirtuin chemical mechanisms

Anthony A. Sauve

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Chemistry, Medicinal

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Jerome C. Bressi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Review Biochemistry & Molecular Biology

Structural studies on human 2-oxoglutarate dependent oxygenases

Michael A. McDonough et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

In Vivo Residue-specific Histone Methylation Dynamics

Barry M. Zee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Pathology

Demystified molecular pathology of NUT midline carcinomas

Christopher A. French

JOURNAL OF CLINICAL PATHOLOGY (2010)

Article Multidisciplinary Sciences

Selective inhibition of BET bromodomains

Panagis Filippakopoulos et al.

NATURE (2010)

Article Genetics & Heredity

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

Gorica Nikoloski et al.

NATURE GENETICS (2010)

Review Genetics & Heredity

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

Sohail Malik et al.

NATURE REVIEWS GENETICS (2010)

Review Biochemistry & Molecular Biology

Fast signals and slow marks: the dynamics of histone modifications

Teresa K. Barth et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Review Biochemistry & Molecular Biology

Polycomb group protein-mediated repression of transcription

Lluis Morey et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Biochemistry & Molecular Biology

The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis

Aron Gyuris et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2009)

Article Biochemistry & Molecular Biology

BisubstrateInhibitors of the MYST HATs Esa1 and Tip60

Jiang Wu et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Cell Biology

An operational definition of epigenetics

Shelley L. Berger et al.

GENES & DEVELOPMENT (2009)

Article Biochemistry & Molecular Biology

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

Yanqi Chang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Chunaram Choudhary et al.

SCIENCE (2009)

Review Genetics & Heredity

What controls nucleosome positions?

Eran Segal et al.

TRENDS IN GENETICS (2009)

Review Medicine, General & Internal

Molecular origins of cancer: Epigenetics in cancer

Manel Esteller

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Cell Biology

Multivalent engagement of chromatin modifications by linked binding modules

Alexander J. Ruthenburg et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

Sean D. Taverna et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

Min Gyu Lee et al.

SCIENCE (2007)

Article Oncology

Characterization of novel inhibitors of histone acetyltransferases

Elena D. Eliseeva et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Article Multidisciplinary Sciences

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

Steen K. T. Ooi et al.

NATURE (2007)

Review Oncology

The role of histone deacetylases (HDACs) in human cancer

Santiago Ropero et al.

MOLECULAR ONCOLOGY (2007)

Article Biochemistry & Molecular Biology

Specific inhibition of p300-HAT alters global gene expression and represses HIV replication

K. Mantelingu et al.

CHEMISTRY & BIOLOGY (2007)

Article Biochemistry & Molecular Biology

High-resolution profiling of histone methylations in the human genome

Artern Barski et al.

Article Multidisciplinary Sciences

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

Yi Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

Discovery and development of SAHA as an anticancer agent

P. A. Marks

ONCOGENE (2007)

Review Biochemistry & Molecular Biology

Chromatin modifications and their function

Tony Kouzarides

Article Biochemistry & Molecular Biology

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

Stefan Kubicek et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

L3MBTL1, a histone-methylation-dependent chromatin lock

Patrick Trojer et al.

Article Multidisciplinary Sciences

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

Hoon Ryu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Paul A. C. Cloos et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Johnathan R. Whetstine et al.

Article Multidisciplinary Sciences

Histone demethylation by a family of JmjC domain-containing proteins

Y Tsukada et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

Min Gyu Lee et al.

CHEMISTRY & BIOLOGY (2006)

Review Biotechnology & Applied Microbiology

Anticancer activities of histone deacetylase inhibitors

Jessica E. Bolden et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Oncology

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

L Stimson et al.

MOLECULAR CANCER THERAPEUTICS (2005)

Article Biochemistry & Molecular Biology

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

D Greiner et al.

NATURE CHEMICAL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

JJ Kovacs et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

hDOT1L links histone methylation to leukemogenesis

Y Okada et al.

Article Biochemistry & Molecular Biology

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

A Nebbioso et al.

NATURE MEDICINE (2005)

Article Biochemistry & Molecular Biology

Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1

YJ Shi et al.

Article Multidisciplinary Sciences

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

CG Kleer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

The polycomb group protein EZH2 is involved in progression of prostate cancer

S Varambally et al.

NATURE (2002)

Article Multidisciplinary Sciences

HDAC6 is a microtubule-associated deacetylase

C Hubbert et al.

NATURE (2002)

Review Biochemistry & Molecular Biology

Transcriptional regulation in acute promyelocytic leukemia

RJ Lin et al.

ONCOGENE (2001)

Article Multidisciplinary Sciences

Deacetylation of p53 modulates its effect on cell growth and apoptosis

JY Luo et al.

NATURE (2000)

Article Multidisciplinary Sciences

Structure and function of a human TAFII250 double bromodomain module

RH Jacobson et al.

SCIENCE (2000)

Article Biochemistry & Molecular Biology

HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF

OD Lau et al.

MOLECULAR CELL (2000)