期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 172, 期 11, 页码 2716-2732出版社
WILEY
DOI: 10.1111/bph.12844
关键词
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资金
- ICREA Funding Source: Custom
Gene expression is dynamically controlled by epigenetics through post-translational modifications of histones, chromatin-associated proteins and DNA itself. All these elements are required for the maintenance of chromatin structure and cell identity in the context of a normal cellular phenotype. Disruption of epigenetic regulation is a common event in human cancer. Here, we review the key protein families that control epigenetic signalling through writing, erasing or reading specific post-translational modifications. By exploiting the leading role of epigenetics in tumour development and the reversibility of epigenetic modifications, promising novel epigenetic-based therapies are being developed. In this article, we highlight the emerging low MW inhibitors targeting each class of chromatin-associated protein, their current use in preclinical and clinical trials and the likelihood of their being approved in the near future. Linked ArticlesThis article is part of a themed section on Epigenetics and Therapy. To view the other articles in this section visit
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